Sex Determination
In the 1940’s, the French embryologist Alfred
Jost observed that when the undifferentiated
gonads were removed from a male rabbit fetus
before male development had begun, it
developed as a female. In 1959, chromosomal
analysis of two disorders in man, Turner syndrome
and Klinefelter syndrome, yielded the
first evidence that genetic factors on the Y chromosomes
of mammals are important in determining
male sex. A specific gene on the mammalian
Y chromosome (SRY, sex-related Y) induces
male sex development during embryogenesis
(sex determination).
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